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spisanie Detski i infektsiosni

Editor:
Central Medical Library ®,
MU - Sofia

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


Journal "Detski i infectsiosni bolesti" (Pediatric and Infectious Diseases)

CURRENT ISSUE

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Vol. 10, 2018

 

Vol. 10, 2018, № 1

CHILD DISEASES

ORIGINAL ARTICLES

М. Boncheva, Chr. Madjova and V. Madjova.Changes in nitrites’ oxidation of saliva in continuous intake of fresh fruit juice of aronia melanocarpa in adolescents with obesity and diabetes mellitus - Detski i infectsiosni bolesti (Pediatric and Infectious Diseases), V. 10, 2018, № 1, 3-8.

М. Boncheva, Chr. Madjova and V. Madjova.Investigating the effect of aronia melanocarpa fresh fruit juice intake on changes in laboratory haematology parameters in adolescents with obesity and diabetes mellitus - Detski i infectsiosni bolesti (Pediatric and Infectious Diseases), V. 10, 2018, № 1, 9-14.

 

INFECTIOUS DISEASES

REVIEWS

V. Doycheva, Y. Mitova and N. Chumak.Epidemic outbreak with Salmonella Agona in Europe associated with infant formula milk - Detski i infectsiosni bolesti (Pediatric and Infectious Diseases), V. 10, 2018, № 1,15-17.

R. Коmitova.Biofilms and biofilms infeсtions - Detski i infectsiosni bolesti (Pediatric and Infectious Diseases), V. 10, 2018, № 1, 18-24.

I. Todorov and M. Gospodinova.Serum amyloid A protein in acute infectious diseases- Detski i infectsiosni bolesti (Pediatric and Infectious Diseases), V. 10, 2018, № 1, 25-36.

B. Borisov and St. Lincova.Infection complications of hemodialisys tunelled catheters – types, diagnosis and treatment strategies - Detski i infectsiosni bolesti (Pediatric and Infectious Diseases), V. 10, 2018, № 1, 37-43.

T. Petkova and Ts. Doychinova.Parvovirus B19 infection and pregnancy - Detski i infectsiosni bolesti (Pediatric and Infectious Diseases), V. 10, 2018, № 1, 44-48.

 

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CHILD DISEASES

 

ORIGINAL ARTICLES

Changes in nitrites’ oxidation of saliva in continuous intake of fresh fruit juice of aronia melanocarpa in adolescents with obesity and diabetes mellitus - Detski i infectsiosni bolesti (Pediatric and Infectious Diseases), V. 10, 2018, № 1, 3-8.
М. Boncheva1, Chr. Madjova2 and V. Madjova1
1Department of Family Medicine and Clinical Laboratory, Faculty of Medicine
2Department of Conservative Dentistry and Oral Health, Faculty of Dental Medicine
Меdical University – Varna
Abstract. Chronic diseases in humans damage not only the whole organism, but also affect the oral cavity. Therefore, saliva is an important indicator for assessing the status of the organism and gives a real idea of the changes in it. The purpose of the present study is to evaluate the oral status and some indicators of oxidative stress in adolescents with obesity and diabetes mellitus and to identify changes in some saliva parameters investigated by two independent tests for nitrite radicals before and after continuous intake of aronia melanocarpa juice. A saliva of 90 subjects, median age 13.95 years was studied (42 healthy controls, 25 with diabetes mellitus, 23 with obesity) with two tests: Nitrite (Diurui Industrial Co. Ltd) and ROSA Test (Diacron Labs S.R.I) as a part of the Caratelli panel. Analyzes were performed before intake and 60 days after intake of fresh fruit juice of aronia melanocarpa. We have confirmed a positive correlation between increased metabolism of oxygen oxidative stress (nitrogenous radicals) and impaired oral status (presence of inflammation) in adolescents with diabetes mellitus and obesity, tested with two independent tests. We have found a significant positive response by reaching of 100% optimal values in the laboratory results of the two tests after a 60-day intake of fresh fruit juice of aronia melanocarpa for the tested patients.
Key words: aronia melanocarpa, diabetes mellitus, oral status, oxidative stress, ROSA Test, Caratelli panel
Address for correspondence: М. Boncheva, MD, Department of Family Medicine and Clinical Laboratory, Faculty of Medicine, Меdical University – Varna, e-mail: mbon@mail.bg

 

Investigating the effect of aronia melanocarpa fresh fruit juice intake on changes in laboratory haematology parameters in adolescents with obesity and diabetes mellitus - Detski i infectsiosni bolesti (Pediatric and Infectious Diseases), V. 10, 2018, № 1, 9-14.
М. Boncheva1, Chr. Madjova2 and V. Madjova1
1Department of Family Medicine and Clinical Laboratory, Faculty of Medicine
2Department of Conservative Dentistry and Oral Health, Faculty of Dental Medicine, Меdical University – Varna
Abstract. The authors investigate the effects of Aronia melanocarpa juice intake on basic blood hematology parameters with an emphasis on hemoglobin and erythrocytes. A blood samples of 90 subjects, median age 13.95 years was studied (42 healthy controls, 25 with diabetes mellitus, 23 with obesity) with hematology analyzer Sysmex HP-300. All subjects have taken 50 ml of juice twice daily over a period of 60 days. We investigated changes in erythrocyte, leukocyte and platelet count, hemoglobin concentration as well as the mathematically calculated HCT, MCV, MCHC, RDW. The results obtained no statistically significant changes in hematological parameters (p = 0.162). Before and after aronia juice intake, these values fluctuate within the reference concentration range. Considerable influence on erythrocyte membrane and hemoglobin function is discussed due to the proven antioxidant effects of the polyphenols contained in the fruits of the aronia melanocarpa and the rich content of minerals, vitamins and trace elements. We recommend the daily intake of Aronia melanocarpa fruit juice as a vital functional food for adolescents with obesity and Type 2 diabetes mellitus.
Key words: aronia melanocarpa, type 2 diabetes mellitus, hemoglobin, erythrocytes
Address for correspondence: М. Boncheva, MD, Department of Family Medicine and Clinical Laboratory, Faculty of Medicine, Меdical University – Varna, e-mail: mbon@mail.bg

 

INFECTIOUS DISEASES

REVIEWS

Epidemic outbreak with Salmonella Agona in Europe associated with infant formula milk - Detski i infectsiosni bolesti (Pediatric and Infectious Diseases), V. 10, 2018, № 1,15-17.
V. Doycheva, Y. Mitova and N. Chumak
Department of Epidemiology, Medical University – Sofia
Abstract. In this overview is described an outbreak of Salmonella Agona linked to the consumption of infant formula milk in France since August 2017. As of 11 January 2018, the outbreak had affected 39 infants under the age of 1 year – 37 in France, 1 in Spain and 1 in Greece. Available evidence from epidemiological investigations in infants and traceability investigations in food identified seven different brands of infant formula from a single processing company in France as the vehicles of infection.
Key words: epidemic outbreak, Salmonella Agona infections, infant formula milk
Address for correspondence: Prof. V. Doycheva, PhD, Chair of Epidemiology, MU Sofia, e-mail: v.doycheva@abv.bg

 

Biofilms and biofilms infeсtions - Detski i infectsiosni bolesti (Pediatric and Infectious Diseases), V. 10, 2018, № 1, 18-24.
R. Коmitova
Department of Infectious Diseases, Parasitology and Tropical Medicine, Faculty of Medicine, Medical University – Plovdiv
Abstract. Bacteria and fungi survive in unfriendly environment forming biofilms. Biofilm is a complex structured consortium of bacteria embedded in a self-produced matrix. Bacterial biofilms are tolerant to antibiotics, disinfectants and defense systems of the body. Biofilm growth is associated with an increased level of mutations. Biofilms are associated with device-related and tissue-related chronic infections. It is estimated that 80% of all chronic infections are associated with biofilms. Тhis review is focused on the structure, formation and trait of biofilm. The management approach of medical biofilm infections is discussed. As most antibiotics have limited effect against biofilm infections, novel prophylactic and therapeutic options are needed.
Key words: bacterial biofilms, biofilm infections, antibiotic tolerance, quorum sensing
Address for correspondence: Prof.  Radka Komitova, PhD, Sv. Georgy Hospital; 4002 Plovdiv

 

Serum amyloid A protein in acute infectious diseases- Detski i infectsiosni bolesti (Pediatric and Infectious Diseases), V. 10, 2018, № 1, 25-36.
I. Todorov and M. Gospodinova
Department of Infectious Diseases, Parasitology and Dermatology, Medical University – Varna
Abstract. The acute phase response is a non-specific reaction of an organism, activated by some processes damaging the tissue such as trauma, inflammation and infections. The essence of this type immune defense consists of various changes in the serum concentration of certain plasma proteins, known as acute phase proteins. One of the most important are C-reactive protein, serum amyloid A protein, procalcitonin, etc. With the present review, authors aim to study the role of serum amyloid A protein as a marker of acute inflammation and to find its place in the laboratory diagnosis of acute infectious diseases. A critical analysis of the national and international literature was made. The molecular structure, expression, functions and kinetics (in healthy and diseased including infectious diseases) of the marker are presented. Our results report undeniable role of serum amyloid A protein as a significant marker of acute inflammation, early diagnosis and effectiveness of the treatment. The idea that serum amyloid A should be а compulsory part of laboratory diagnosis in acutely infected person, is proposed.
Key words: acute phase response, acute phase proteins, immune defense, amyloid A, C-reactive protein, Infections
Адрес за кореспонденция: I. Todorov, MD, Department of Infectious Diseases, Parasitology and Dermatology, Medical University – Varna; Mob. tel.: +359 52 978 710; e-mail: ilio_87@abv.bg


Infection complications of hemodialisys tunelled catheters – types, diagnosis and treatment strategies - Detski i infectsiosni bolesti (Pediatric and Infectious Diseases), V. 10, 2018, № 1, 37-43.
B. Borisov and St. Lincova
Clinic of Nephrology and Dialysis, Medical University – Pleven
Abstract. The number of patients with chronic renal failure (CRF) treated with hemodialysis (HD) increases annually globally. One of the main factors determining the quality of their lives is the type of vascular access used. Tunnel catheters have entered the medical practice since 1987. Regardless of the recommendations for their use in up to 10% of hemodialysis patients, their relative share has risen in the last two decades two to three times in the countries of Europe, and in the United States and Canada there are over 40% of the access for hemodialysis treatment. The present literature review aims to present the main complication in their use – catheter-related infections. The different types of infectious complications, their pathogenesis, their laboratory diagnostics and practical guidelines for the behavior of each of them are examined.
Key words: hemodialysis, tunnelled catheters, infection complications
Адрес за кореспонденция: B. Borisov , MD, Clinic of Nephrology and Dialysis, Medical University – Pleven; e-mail: biserugo@abv.bg

 

Parvovirus B19 infection and pregnancy - Detski i infectsiosni bolesti (Pediatric and Infectious Diseases), V. 10, 2018, № 1, 44-48.
T. Petkova and Ts. Doychinova
Department of Infectious Diseases, Epidemiology, Parasitology and Tropical medicine,Faculty of Public Health, Medical University – Pleven
Abstract. Erythema infectiosum (Fifth Disease, Parvovirus B19 infection) is an airborne disease caused by Parvovirus B19. Usually the disease has benign course in children. In 10-17% of cases by non-immune pregnant women vertical transmission is proved, presenting with severe anemia, non-immune hydrops or loss of the fetus. According to data from serological studies, 30-50% of women in reproductive age are seronegative and form a group of risk for infection with the virus. In terms of absent specific antiviral therapy and vaccine prophylaxis, advisable prevention of women in childbearing age includes screening of the antibody status. The literature review presents current recommendations about diagnostic approaches and disease prevention in pregnant women.
Key words: Erythema infectiosum, Parvovirus B19, pregnancy
Адрес за кореспонденция: Ass. Prof.T. Petkova, PhD, Department of Infectious Diseases, Epidemiology, Parasitology and Tropical medicine,Faculty of Public Health, Medical University – Pleven, e-mail: tanja_1973@abv.bg

 


Last update: 06.03.2018'

 


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