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spisanie Detski i infektsiosni

Editor:
Central Medical Library ®,
MU - Sofia

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


Journal "Detski i infectsiosni bolesti" (Pediatric and Infectious Diseases)

CURRENT ISSUE

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Vol. 9, 2017

 

Vol. 9, 2017, № 2

CHILD DISEASES

REVIEWS

E. Ivanova and Sn. Mihaylova. Immunological disturbances in patients with autism spectrum disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 3-8. .

ORIGINAL ARTICLES

Zh. Ruseva, M. Milkov, Ch. Madjova and V. Madjova. Alternative methods for treatment of children with syndrome disturbing breathing and tonsillar hypertrophy disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 9-13.

S. Tsankov, T. Vekov and N. Veleva. Cost-effectiveness analysis of therapeutic alternatives for treatment of Gausher disease in Bulgaria, 2017 disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 14-18.

 

INFECTIOUS DISEASES

REVIEWS

V. Doycheva, Y. Mitova, Ts. Mincheva and J. Donkov. Epidemiological characteristics of viral hepatitis E in Europe disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 19-22.

V. Doycheva, Y. Mitova, J. Donkov and Ts. Mincheva. Modern epidemiological characteristics and distribution of plague in the world  disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 23-27.

ORIGINAL ARTICLES

T. Vekov and S. Tsankov. Economic assessment of interferon-free drug therapies for treatment of chronic viral hepatitis C in Bulgaria, 2017 disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 28-34.

V. Irmov and P. Petrov. Awareness of Bulgarian women regarding the ways of prevention of sexually transmitted infections disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 35-38.

 

 

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CHILD DISEASES

REVIEWS

Immunological disturbances in patients with autism spectrum disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 3-8.
E. Ivanova1 and Sn. Mihaylova2
1Clinic of Psychiatry, UMHAT “Alexandrovska” – Sofia
2Clinic of Clinical immunology with Stem Cell Bank, UMHAT “Alexandrovska” – Sofia
Abstract. Data from the medical literature on immunological examinations conducted in patients with autism spectrum disorders reveals the presence of disorders in cellular and humoral immunity, immunoglobulins, serum levels and genetic polymorphisms of some of the cytokines, presence of autoantibodies, etc., possibly related to the predisposition for the development of this disease, its course and the severity of its clinical symptoms. Research efforts are focused on the development of immunological biomarkers to be used for diagnostic, therapeutic and prognostic purposes in patients with autism spectrum disorders.
Key words: autism spectrum disorders, immunological disorders
Address for correspondence:  E. Ivanova,  MD, 1 Clinic of Psychiatry, UMHAT “Alexandrovska” – Sofia; GSM: 0895472527   е-mail: helen_aivan@abv.bg

 

ORIGINAL ARTICLES

Alternative methods for treatment of children with syndrome disturbing breathing and tonsillar hypertrophy disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 9-13.
Zh. Ruseva1, M. Milkov2, Ch. Madjova3 and V. Madjova1
1Department of Family Medicine and Clinical Laboratory, Faculty of Medicine
2Department of Prosthetic Dentistry and Orthodontics, Faculty of Dental Medicine
3Department of Conservative Dentistry and Oral Pathology, Faculty of Dental Medicine
Medical University “Prof. Dr. Paraskev Stoyanov” – Varna
Abstract. The tonsils have the highest immunological activity in children of early and school age. With the start of their social life – visits to nurseries and schools, infections of various viral and bacterial causesand allergies can lead to the pathological growth of tonsils. It is assumed that tonsillar hypertrophy is an enlargement 3+ and 4+ g rade of tonsils found by pharyngoscopy. It is frequently accompanied with the socalled syndrome of sleep-disordered breathing (SDB) as a combination of diseases ranging from primary snoring to obstructive sleep apnea (OSA). A major method for treatment of tonsillar hypertrophy is surgical – tonsillectomy or tonsillotomy. In recent years, negative attitudes towards surgical treatment are seen in some parents and the demand for alternative methods of treatment with unproved effect has increased. We present a pilot study for evaluation of a scientifi cally-based physiotherapeutic program for the treatment of tonsillar hypertrophy and associated sleep breathing disorders in 32 children aged 3-10 years. The obtained data indicate a positive trend of the monitored parameters, which gives us a reason to think that the applied physiotherapy treatment is suitable as an alternative therapy of the surgical treatment in oftenly ill children with tonsillar hypertrophy.
Key words: treatment of children, tonsillar hypertrophy, sleep-disordered breathing syndrome
Address for correspondence::  Zh. Ruseva MD; Department of Family Medicine and Clinical Laboratory, Faculty of Medicine, Medical University “Prof. Dr. Paraskev Stoyanov” – Varna

 

Cost-effectiveness analysis of therapeutic alternatives for treatment of Gausher disease in Bulgaria, 2017 disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 14-18.
S. Tsankov, T. Vekov and N. Veleva
Faculty of Pharmacy, Medical University – Pleven
Abstract. The aim of study is to identify and analyze published data from health technologies assessments for treatment of patients with Gausher disease type 1 (GD1), performed in foreign countries; to model expenses and health benefi ts of the available in local clinical practice therapeutic alternatives; to validate and defi ne cost-effective therapeutic alternatives for first line therapy in Bulgaria. The performed literature search on data bases such as MEDLINE, EMBASE, Cochrane Library, found 3 correlative analyses of the type cost/effectiveness (cost-effectiveness analysis – CEA) of health technologies for treatment of patients with GD1 – imiglucerase (IMI), velaglucerase (VEL), miglustat (MIG), eliglustat (ELI). For modeling of expenses and health benefi ts of administered therapeutic alternatives in Bulgaria, it is used the Markov's model with eight health conditions describing possible development of disease and refl ecting all probabilities for transition from one health condition to another. Time horizon of the model is life-long. Costs and benefi ts are discounted with 5% annually. The selected perspective of the model is healthy from the point of view of the payer. Results from the performed cost-effectiveness analysis show that ЕLI dominates IMI with similar therapeutic effectiveness and signifi cantly lower costs (BGN -207,880) for annual therapy. Besides, ELI is an irreplaceable substrate-reduction therapy in the patients, for whom enzyme-replacement therapy is inappropriate and adverse drug reactions occur in therapy with MIG.
Key words:
Gausher disease type 1, cost-effective therapeutic alternatives/fi rst line therapy, substratereduction therapy, enzyme-replacement therapy, cost-effectiveness analysis
Address for correspondence: Prof. T. Vekov; e-mail: t.vekov.mu.pleven@abv.bg

 

INFECTIOUS DISEASES

REVIEWS

Epidemiological characteristics of viral hepatitis E in Europe disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 19-22.
V. Doycheva, Y. Mitova, Ts. Mincheva and J. Donkov
Department of Epidemiology, Medical University – Sofia
Abstract. In the last 10 years the number of the patients with HEV has been increasing in European countries and shows variability among different geographical areas. In this review we describe the general epidemiological characteristics of HEV and the serological data in different European countries. Subtypes 3e and f of HEV are the main genotypes detected in the European population. Sporadic cases of autochthonous genotype 4 have been described in Spain, France and Italy. The patients are predominantly male, over 50 years of age. The subclinical form is the most frequent. Fulminant form is rare, predominantly in pregnant women and it was related to genotype 3 of virus.
Key words: viral hepatitis E infection, hepatitis E virus (HEV), genotypes, epidemiological characteristics
Address for correspondence:   Prof. V. Doycheva, MD, PhD, Chair of Epidemiology, MU-Sofia, Zdrave Str No2, 1431 Sofia, e-mail: v.doycheva@abv.bg

 

Modern epidemiological characteristics and distribution of plague in the world  disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 23-27.
V. Doycheva, Y. Mitova, J. Donkov and Ts. Mincheva
Department of Epidemiology, Medical University – Sofia
Abstract. Plague is a bacterial zoonotic infection transmitted by fl eas. The geographical distribution of the disease is strictly localized. The pathogen Yersinia pestis infects humans through infected fl ea bites. Human plague is a serious disease, particularly in its septicaemic and pneumonic forms. The principal animal reservoir and local socioeconomic conditions are determinants of the epidemiological characteristics of the disease and the risk of transmission to human. Plague is a disease of poverty in Africa, South America and Asia (India), where the animal reservoir essentially comprises commensal rodents, but tends to be sporadic disease associated with outdoor occupation in the other endemic regions.
Key words: plague, Yersinia pestis, epidemiological characteristics, geographical distribution
Address for correspondence:
   Prof. V. Doycheva, MD, PhD, Chair of Epidemiology, MU-Sofia, Zdrave Str No2, 1431 Sofia, e-mail: v.doycheva@abv.bg


ORIGINAL ARTICLES

Economic assessment of interferon-free drug therapies for treatment of chronic viral hepatitis C in Bulgaria, 2017 disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 28-34.
T. Vekov and S. Tsankov
Faculty of Pharmacy, Medical University – Pleven
Abstract. Chronic hepatitis C (CHC) is a socially signifi cant disease. Current therapeutic approaches for its treatment are based on combined interferon-free therapies including ombitasvir/ paritaprevir/ ritonavir/ dasabuvir/ ribavirin (OMВ/PAR/RIT/DAS/R), sofosbuvir/ledipasvir (SOF/LED), elbasvir/grazoprevir (ELB/GRA) and also the innovative pangenotypic therapies glecaprevir/pibrentasvir (GLE/PIB), sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX), grazoprevir/uprifosbuvir/elbasvir (GRA/UPR/ELB). The aim of presented study is to collect and analyze published data from assessments of health technologies for treatment of CHC in foreign countries, and to model expenses and health benefi ts of innovative pangenotypic therapies compared to other interferon-free therapies SOF/LED, ELB/GRA, OMB/ PAR/ RIT/ DAS/R; to make an indirect comparison of the therapeutic and cost-effectiveness of the alternatives for treatment of CHC based on network analysis. The results of ongoing assessment of health technologies for treatment of CHC are confi rmed by published data from similar relevant assessments made in foreign countries. Based on performed analyses, the conclusion can be drawn that in the group of interferon-free therapeutic alternatives for treatment of CHC in Bulgaria GLE/PIB and OMB/PAR/PIT/DAS/R dominate SOF/LED and ELB/GRA with a better therapeutic effi cacy and lower expenses per therapeutic course.
Key words: chronic hepatitis C, combined interferon-free therapies, innovative pangenetic therapies, assessments of health technologies, therapeutic and cost-effectiveness
Address for correspondence::   Prof. T. Vrkov, e-mail: t.vekov.mu.pleven@abv.bg

 

Awareness of Bulgarian women regarding the ways of prevention of sexually transmitted infections disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 35-38.
V. Irmov1 and P. Petrov2
1University Clinic „Deva Maria“ – Bourgas,
2MHAT “Eskulap” – Pazardzhik
Abstract. In the case of the Bulgarians, the number of women who have stated that they are fully aware of how to protect themselves against sexually transmitted infections is unsatisfactorily high. Only a 1/4 of all participants in the study are well aware of the methods and ways to protect against sexually transmitted infections. With the elevated education of the women surveyed also the relative share of women reporting that they know in details the ways and means of prevention of infectious diseases transmitted by sexual intercourse increased. We found that the age of the respondents infl uenced their knowledge of the methods for the prevention of infectious diseases transmitted by sexual intercourse. The presence of infectious diseases in the previous history of respondents also has an impact on their knowledge of the prevention of sexually transmitted infections.
Key words: prophylactics, literacy, infectious diseases, influence
Address for correspondence:   P. Retrov, MD, е-mail: dr.petroff@abv.bg


Last update: 14.12.2017

 


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