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spisanie Detski i infektsiosni

Editor:
Central Medical Library ®,
MU - Sofia

 

 

 

 

 



 

 


 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


Journal "Detski i infectsiosni bolesti" (Pediatric and Infectious Diseases)

REVIEWS

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Vol. 8, 2016

Vol. 8, 2016, № 2

INFECTIOUS DISEASES
REVIEWS

N. Yancheva-Petrova. HIV-assosiated lymphomas - Detski i infectsiosni bolesti, V. 8, 2016, No2, 18-27. (Abstract)

K. Terzieva, I. Popivanov, V. Doycheva, Tz. Doychinova and D. Shalamanov. Development of the knowledge and prospects of the modern epidemiological control of hepatitis B and hepatitis C - Detski i infectsiosni bolesti, V. 8, 2016, No2, 28-36. (Abstract)

M. Baymakova. Fever of unknown origin in the elderly over 65 years old - Detski i infectsiosni bolesti, V. 8, 2016, No2, 37-42. (Abstract)

 

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Vol. 8, 2016, № 1

CHILD DISEASES
REVIEWS

Sn. Lazova, Тs. Velikova, G. Petrova, E. Ivanova-Todorova, K. Tumangelova-Yuzeir, D. Kyurkchiev and P. Perenovska. Immunological face of pediatric asthma - Detski i infectsiosni bolesti, V. 8, 2016, No1, 8-15. (Abstract)

M. Boncheva and N. Konova. Laboratory testing of highly sensitive C-reactive protein (hsCRP) for thе needs in neonatology - Detski i infectsiosni bolesti, V. 8, 2016, No1, 16-18. (Abstract)

INFECTIOUS DISEASES

V. Doycheva, Y. Mitova-Mineva, J. Donkov and V. Vodenicharov. Epidemiological characteristics of HIV infection and AIDS in europe and Bulgaria 2014-2015 - Detski i infectsiosni bolesti, V. 8, 2016, No1, 30-37. (Abstract)

Ts. Mincheva, Ts. Doychinova, V. Doycheva, I. Popivanov, K. Terzieva and D. Shalamanov. Clinical indicators of anthrax infection as elements of epidemiological investigation - Detski i infectsiosni bolesti, V. 8, 2016, No1, 38-45. (Abstract)

Ts. Doychinova, V. Doycheva, Ts. Mincheva, K. Terzieva, D. Georgieva, I. Popivanov and D. Shalamanov. Laboratory indicators as elements of epidemiological investigation in anthrax - Detski i infectsiosni bolesti, V. 8, 2016, No1, 46-53. (Abstract)

D. Ilieva, M. Staleva and R. Petrova. Monitoring of tetracycline detection in districts with oral vaccination of foxes against rabies in 2015 - Detski i infectsiosni bolesti, V. 8, 2016, No1, 54 -59. (Abstract)

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2016, № 2

INFECTIOUS DISEASES

REVIEWS

HIV-assosiated lymphomas - Detski i infectsiosni bolesti, V. 8, 2016, No2, 18-27.
N. Yancheva-Petrova
Ward for Acquired Immune Defi ciency, SHATIPB “Prof. Ivan Kirov”,
Department for Infectious Diseases, Parasitology and Tropical Medicine, Medical University – Sofia
Summary. People infected with human immunodefi ciency virus (HIV) have higher risk of developing lymphomas compared to the rest population. Following the advent of effective prophylactic regimens for common opportunistic infections (eg. Pneumocystis jiroveci, Toxoplasma gondii, Cytomegalovirus) and the development of antiretroviral therapy, the incidence of HIV-associated lymphomas decreased from 4% to 1.6% per year. Without effective antiretroviral therapy, it is estimated that 5-10% of all HIV-infected individuals will have lymphoma as either an initial or subsequent AIDS-defi ning condition.Therefore antiretroviral therapy combined with antilymphomic chemotherapy improves outcome and survival.
Key words: HIV-assosiated lymphoma, NHL, highly active antiretroviral therapyDepartment “Epidemiology”, Medical University – Sofia
Address for correspondence: N. Yancheva-Petrova, MD, e-mail: dr.yancheva@abv.bg


Development of the knowledge and prospects of the modern epidemiological control of hepatitis B and hepatitis C - Detski i infectsiosni bolesti, V. 8, 2016, No2, 28-36.
K. Terzieva(1), I. Popivanov(2), V. Doycheva(3), Tz. Doychinova(1) and D. Shalamanov(1)
(1)Department „Infectious Diseases, Epidemiology, Parasitology and Tropical Medicine“, Medical University – Pleven
(2)Department of Military Medicine, Military Medical Academy – Sofia
(3)Department of Epidemiology, Medical University – Sofia
Summary. The process of accumulation of scientifi c knowledge about hepatitis B and hepatitis C was discussed. A comparative review of health-social importance was made and some key elements of the epidemiological characteristic of these two infections were analyzed. A prognosis was made and the prospects for prevention of hepatitis C were summarized.
Key words: viral hepatitis type B, viral hepatitis type C, epidemiological characteristics, prevention, prognosis
Address for correspondence: K. Terzieva, MD,Medical University - Pleven, tel.:+35964 884 225, e-mail: kali7@abv.bg



Fever of unknown origin in the elderly over 65 years old - Detski i infectsiosni bolesti, V. 8, 2016, No2, 37-42.
M. Baymakova
Department of Infectious Diseases, Military Medical Academy – Sofia
Summary. The febrile reaction in elderly is infl uenced by a combination of variety of factors which lead to blunted or absent febrile response. The defi nition of fever in elderly is reconsidered and other parameters of the fever are applied as defi nition. Due to that the people older than 65 years with fever of unknown origin (FUO) are separated from classic FUO in a special subgroup called FUO in elderly. Published data established a great percentage of diagnosed cases of FUO in geriatric patients and a prevalence of infection as a main reason for the persisting fever.
Key words: fever of unknown origin, infectious diseases, elderly
Address for correspondence: M. Baymakova, MD, PhD, e-mail: dr.baymakova@gmail.com

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2016, № 1

CHILD DISEASES -

REWIEWS

Immunological face of pediatric asthma - Detski i infectsiosni bolesti, V. 8, 2016, No1, 8-15.
Sn. Lazova(1), Тs. Velikova(2), G. Petrova(1), E. Ivanova-Todorova(2), K. Tumangelova-Yuzeir(2),
D. Kyurkchiev2 and P. Perenovska(1)
(1)Pediatric Clinic, University Hospital “Alexandrovska” – Sofia
(2)Clinical Immunology Laboratory, University Hospital “St. Ivan Rilski” – Sofia

Summary.
Asthma is one of the most common chronic diseases in childhood. It is characterized by immune-mediated chronic inflammation of the airways, in the pathogenesis of which numerous cells – T lymphocytes, mast cells, basophils, IgE-producing plasma cells, epithelial cells, fibroblasts, smooth muscle cells of bronchi, and large array of cytokines (IL-6, IL-8, IL-12, IL-4, IL-10, IL-13, IFN-γ, IL-17) play an important role. For decades it is accepted that asthma is mediated by Th2 (T Helper Type 2) lymphocytes expressing IL-4 that supports the switching to IgE synthesis; by IL-5 required for development and differentiation of eosinophils; and also by IL-13, which mediates mucosal hyper-responsiveness through direct effects on epithelial and smooth muscle cells. A „new“ subset of CD4 Th-lymphocytes (Th17), mainly producing IL-17 shows a critical role in the pathogenesis of many diseases including bronchial asthma. There is evidence that an increased level of IL-17 is an independent risk factor for severe asthma and is associated with exacerbation of asthma, decreased response to treatment, accumulation of granulocytes, and production of fibrotic mediators and remodeling of the airway with marked eosinophilia. Any additional knowledge related to the pathogenesis of asthma and the role of certain biomarkers is a step towards an early diagnosis, a possibility for fast achieving and maintaining control of the disease and significant improvement of quality of life of children.
Key words: childhood asthma, biomarkers, cytokines, Th17 lymphocytes, vitamin D
Address for correspondence:
Sn. Lazova - MD, Alexandrovska hospital; Medical University– Sofia.




Laboratory testing of highly sensitive C-reactive protein (hsCRP) for thе needs in neonatology - Detski i infectsiosni bolesti, V. 8, 2016, No1, 16-18.
M. Boncheva(1),(2) and N. Konova(1)
(1)University Hospital „Lozenets” – Sofia
(2)Department of General Medicine and Clinical Laboratory, Medical University – Varna
Summary. In recent decades, progress in the intensive treatment of diseases in the neonatal period leads to impressive decline in mortality. Laboratory markers of sepsis help for early detection of this condition and control treatment. Investigation of C-reactive protein (CRP) presents as a routine parameter in neonatology. Our aim is to explain the differences in survey methodology of CRP and hsCRP, and clinical interpretation of the results of the two methods in newborn children. We believe that this will be useful information for physicians neonatologists.
Key words: hsCRP, newborns, sepsis
Address for correspondence: Ass. Prof. M. Boncheva; Sofia University "Sv. Kl. Ohridski"; tel. 0888680551
e-mail: mbon@mail.bg

 

INFECTIOUS DISEASES - 2016, № 1

REWIEWS

Epidemiological Epidemiological characteristics of HIV infection and AIDS in europe and Bulgaria 2014-2015 - Detski i infectsiosni bolesti, V. 8, 2016, No1, 30-37.
V. Doycheva(1), Y. Mitova-Mineva(1), J. Donkov(1) and V. Vodenicharov(2)

(1)Department of Epidemiology, Medical University – Sofia
(2)Department of Hygiene, Medical Ecology and Nutrition, Medical University – Sofia
Summary. HIV infection is of major public health importance in the EU/EEA during the past decade (2005-2014). In this period there have been important changes of epidemiological characteristics of HIV infection in EC/EEA. Men who have sex with men accounted for the majority of cases diagnosed in 2014 – 42%. Heterosexual and injecting drug users infections are declining. Nearly half (47%) of persons diagnosed with HIV had CD4 cell count < 350/mm3 at diagnosis. Expansion of HIV counseling and testing will ensure early diagnosis and access to treatment.
Key words: HIV infection, epidemiological characteristics, measures for control and surveillance
Address for correspondence: Ass. Prof. V. Doycheva, Department of Epidemiology, Medical University – Sofia; tel. +3592952 38 44; e-mail: v.doycheva@abv.bg.



Clinical indicators of anthrax infection as elements of epidemiological investigation - Detski i infectsiosni bolesti, V. 8, 2016, No1, 38-45.
Ts. Mincheva(1), Ts. Doychinova(2), V. Doycheva(1), I. Popivanov(3), K. Terzieva(2) and D. Shalamanov(2)

(1)Medical University – Sofia,
(2)Medical University – Pleven,
(3)Military Medical Academy – Sofia
Summary. The main characteristics of clinical forms of Anthrax infection in terms of epidemiological theory and practice are presented. For that purpose observations of the last major epidemic situations are discussed. Relationship between factors from the external environment that are relevant to the implementation of the causative agent and determined the epidemiology of infection and the pathogenetic mechanisms occurring in the affected systems and organs are considered. On this base the aspects of clinical course of the infection relevant to epidemiological investigation contributing to clarify the role of the different sources of infection and the possible factors for delivering the biopathogen in human organism are depicted. This article expresses the experience of our observations of advanced epidemiological investigations published in specialized literature. The leading orienting points of clinical manifestations of the disease which should be considered in epidemiological practice are deduced. Rational use of current knowledge in this field can contribute to better focus on preventive measures in epidemic outbreak.
Key words: anthrax infection, clinical forms, epidemiological investigation
Address for correspondence: Ts. Mincheva - MD, Department of Epidemiology, Medical University – Sofia;
tel. +3592 9523844



Laboratory indicators as elements of epidemiological investigation in anthrax - Detski i infectsiosni bolesti, V. 8, 2016, No1, 46-53.
Ts. Doychinova(1), V. Doycheva(2), Ts. Mincheva(2), K. Terzieva(1), D. Georgieva(1), I. Popivanov(3) and D. Shalamanov(1)
(1)Department of Infectious Diseases, Epidemiology, Parasitology and Tropical Medicine, Faculty of Public Health, Medical University – Pleven
(2)Department of Epidemiology, Medical University – Sofia
(3)Department of Military Medicine, Military Medical Academy – Sofia
Summary. The laboratory methods to substantiate B. anthracis in humans are discussed. The diagnostic tests used for laboratory confirmation in classical forms (skin, intestinal and pulmonary) as well as new injection form are characterized. The usage of each method for epidemiological investigation is discussed. The methodological base for detection of the causative agent in foods and air, which appears to be vehicles of infection, is specified. By the perspective of biological protection in general a contemporary system for detection and identification of B. anthracis in the air is presented.
Key words: bacillus anthracis, diagnostic methods, epidemiological investigation, biological safety
Address for correspondence: Ass. Prof. D. Shalamanov, Department of Infectious Diseases, Epidemiology, Parasitology and Tropical Medicine, Faculty of Public Health, Medical University – Pleven; tel. +35964 884 225; e-mail dshalamanov@abv.bg



Monitoring of tetracycline detection in districts with oral vaccination of foxes against rabies in 2015 - Detski i infectsiosni bolesti, V. 8, 2016, No1, 54 -59.
D. Ilieva, M. Staleva and R. Petrova

National Diagnostic Research Veterinary Medical Institute – Sofia
Summary. In 2015 in the Bulgarian districts with oral vaccination against rabies, monitoring of tetracycline and age determination of foxes was carried out. Data obtained from a study of 1662 samples of fox tееth (Vulpes vulpes) for the presence of biomarker are analyzed. The tooth samples were collected from a total of 480 settlements in 22 districts in the country, from the places of distribution of the vaccine baits. The data indicated that the rate of prevalence of positive for tetracycline tееth from foxes amounts to 64.7%.
Key words: biomarker tetracycline, oral vaccination, rabies, foxes
Address for correspondence: Ass. Prof. D. Ilieva, Head of the National Reference Laboratory "Rabies and Monitoring of the Effectiveness of the Vaccination", ND & RVMI – Sofia; e-mail: emd@mail.orbitel.bg

 

 

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Last update: 20.03.2017