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spisanie Detski i infektsiosni

Editor:
Central Medical Library ®,
MU - Sofia

 

 

 

 

 



 

 


 

 

 

 

 


Journal "Detski i infectsiosni bolesti" (Pediatric and Infectious Diseases)

REVIEWS

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Vol. 5, 2013, № 2

INFECTIOUS DISEASES
REVIEWS

I. Todorov, D. Bliznakova and M. Gospodinova. CMV infections and kydneys - Detski i infectsiosni bolesti, V. 5, 2013, No2, 15-22.

 

CMV INFECTIONS AND KYDNEYS - DETSKI I INFECTIOSIOSNI BOLESTI, V. 5, 2013, No2, 15-22.
I. Todorov (1), D. Bliznakova(2) and M. Gospodinova(1)

(1)Department of Infectious Diseases, Epidemiology and Tropical medicine, Medical University – Varna
(2)Section of Pediatrics and Infectious Diseases, Faculty of Dental Medicine, Medical University – Varna
Summary. Cytomegalovirus (CMV) is a member of the family Herpesviridae. It has a double-strand DNA, capsid and a lipoprotein envelope. It can be seen all over the world, but most common in developing countries. Between 50% and 80% of people in the United States have had a CMV infection by the time they are 40 years old, according to the Centers for Disease Control and Prevention (CDC). In our days, this kind of virus causes clinical symptoms in all ages. Once a person has had a CMV infection, the virus usually lies dormant (or inactive) in the body. The reactivation is rare, but most common in cases of depressed immune system – for example after kidney transplantation. The connection between CMV and kidneys is demonstrated by contemporary clinical researches which show us, CMV is one of the most important reasons for developing nephritis as a congenital infection or for developing conditions like membranous nephritis, nephrotic syndrome and mesangial sclerosis. Objective: to evaluate clinical thinking about CMV infection that can cause renal problems or rejection of kidney transplant in relevant patient. Material and methods: we introduce literature references about: the frequency of CMV infection, despite of patient’s age and about its etiologic role in diseases like membranous nephritis, nephrotic syndrome and mesangial sclerosis. Results: in patients that took part in these clinical studies, the specific antiviral treatment results in full remission of the symptoms. Conclusions: 1. Cases of CMV infections become very common in patients of all ages. 2. There is a connection between CMV infection and renal diseases and it is undeniable. 3. CMV is the major cause of fever of unknown origin and rejection of transplant in kidney transplant patients. 4. CMV is the most important reason for congenital nephritis in child, born by seropositive mothers.
Key words: cytomegalovirus, CMV infection, renal transplantation, nephritis, treatment
Address for correspondence: I. Todorov, Department of Infectious Diseases, Epidemiology and Tropical medicine, Medical University – Varna

 

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Last update: 11.03.2014