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spisanie Detski i infektsiosni

Editor:
Central Medical Library ®,
MU - Sofia

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


Journal "Detski i infectsiosni bolesti" (Pediatric and Infectious Diseases)

ORIGINAL PAPERS

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Vol. 9, 2017

Vol. 9, 2017, № 2

CHILD DISEASES

Zh. Ruseva, M. Milkov, Ch. Madjova and V. Madjova. Alternative methods for treatment of children with syndrome disturbing breathing and tonsillar hypertrophy disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 9-13. (Abstract)

S. Tsankov, T. Vekov and N. Veleva. Cost-effectiveness analysis of therapeutic alternatives for treatment of Gausher disease in Bulgaria, 2017 disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 14-18. (Abstract)

 

INFECTIOUS DISEASES

T. Vekov and S. Tsankov. Economic assessment of interferon-free drug therapies for treatment of chronic viral hepatitis C in Bulgaria, 2017 disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 28-34. (Abstract)

V. Irmov and P. Petrov. Awareness of Bulgarian women regarding the ways of prevention of sexually transmitted infections disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 35-38. (Abstract)

 

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Vol. 9, 2017, № 1

CHILD DISEASES
CASE REPORTS

E. Ivanova and P. Manolova-Koleva. Three cases of schizophrenia in adolescents with minimal physical anomalies and stuttering - Detski i infectsiosni bolesti, V. 9, 2017, No1, 9-12. (Abstract)

 

INFECTIOUS DISEASES
ORIGINAL ARTICLES

Angelova, S., Y. Mitova, V. Doycheva, Ts. Mincheva and N.Chumak-Tsaneva. Epidemiological characteristics of nosocomial outbreaks of the “indicator nosocomial infections” group in Bulgaria - Detski i infectsiosni bolesti, V. 9, 2017, No1, 29-32. (Abstract)

D. Ilieva. Investigation of the sensitivity of in vitro diagnostic veterinary medicine means with technique of fluorescent antibody test - Detski i infectsiosni bolesti, V. 9, 2017, No1, 33-36. (Abstract)

CASE REPORT

K. Drenska, I. Dimitrov, A. Kaprelyan, T. Drenski, D. Arabadzhieva, V. Staneva and R. Georgiev. Multiple sclerosis and lyme disease – a case report and literature review - Detski i infectsiosni bolesti, V. 9, 2017, No1, 37-40. (Abstract)

 

 

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2/2016

CHILD DISEASES

Alternative methods for treatment of children with syndrome disturbing breathing and tonsillar hypertrophy disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 9-13.
Zh. Ruseva1, M. Milkov2, Ch. Madjova3 and V. Madjova1
1Department of Family Medicine and Clinical Laboratory, Faculty of Medicine
2Department of Prosthetic Dentistry and Orthodontics, Faculty of Dental Medicine
3Department of Conservative Dentistry and Oral Pathology, Faculty of Dental Medicine
Medical University “Prof. Dr. Paraskev Stoyanov” – Varna
Abstract. The tonsils have the highest immunological activity in children of early and school age. With the start of their social life – visits to nurseries and schools, infections of various viral and bacterial causesand allergies can lead to the pathological growth of tonsils. It is assumed that tonsillar hypertrophy is an enlargement 3+ and 4+ g rade of tonsils found by pharyngoscopy. It is frequently accompanied with the socalled syndrome of sleep-disordered breathing (SDB) as a combination of diseases ranging from primary snoring to obstructive sleep apnea (OSA). A major method for treatment of tonsillar hypertrophy is surgical – tonsillectomy or tonsillotomy. In recent years, negative attitudes towards surgical treatment are seen in some parents and the demand for alternative methods of treatment with unproved effect has increased. We present a pilot study for evaluation of a scientifi cally-based physiotherapeutic program for the treatment of tonsillar hypertrophy and associated sleep breathing disorders in 32 children aged 3-10 years. The obtained data indicate a positive trend of the monitored parameters, which gives us a reason to think that the applied physiotherapy treatment is suitable as an alternative therapy of the surgical treatment in oftenly ill children with tonsillar hypertrophy.
Key words: treatment of children, tonsillar hypertrophy, sleep-disordered breathing syndrome
Address for correspondence:  Zh. Ruseva MD; Department of Family Medicine and Clinical Laboratory, Faculty of Medicine, Medical University “Prof. Dr. Paraskev Stoyanov” – Varna

 

Cost-effectiveness analysis of therapeutic alternatives for treatment of Gausher disease in Bulgaria, 2017 disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 14-18.
S. Tsankov, T. Vekov and N. Veleva
Faculty of Pharmacy, Medical University – Pleven
Abstract. The aim of study is to identify and analyze published data from health technologies assessments for treatment of patients with Gausher disease type 1 (GD1), performed in foreign countries; to model expenses and health benefi ts of the available in local clinical practice therapeutic alternatives; to validate and defi ne cost-effective therapeutic alternatives for first line therapy in Bulgaria. The performed literature search on data bases such as MEDLINE, EMBASE, Cochrane Library, found 3 correlative analyses of the type cost/effectiveness (cost-effectiveness analysis – CEA) of health technologies for treatment of patients with GD1 – imiglucerase (IMI), velaglucerase (VEL), miglustat (MIG), eliglustat (ELI). For modeling of expenses and health benefi ts of administered therapeutic alternatives in Bulgaria, it is used the Markov's model with eight health conditions describing possible development of disease and refl ecting all probabilities for transition from one health condition to another. Time horizon of the model is life-long. Costs and benefi ts are discounted with 5% annually. The selected perspective of the model is healthy from the point of view of the payer. Results from the performed cost-effectiveness analysis show that ЕLI dominates IMI with similar therapeutic effectiveness and signifi cantly lower costs (BGN -207,880) for annual therapy. Besides, ELI is an irreplaceable substrate-reduction therapy in the patients, for whom enzyme-replacement therapy is inappropriate and adverse drug reactions occur in therapy with MIG.
Key words:
Gausher disease type 1, cost-effective therapeutic alternatives/fi rst line therapy, substratereduction therapy, enzyme-replacement therapy, cost-effectiveness analysis
Address for correspondence: Prof. T. Vekov; e-mail: t.vekov.mu.pleven@abv.bg

 

INFECTIOUS DISEASES

Economic assessment of interferon-free drug therapies for treatment of chronic viral hepatitis C in Bulgaria, 2017 disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 28-34.
T. Vekov and S. Tsankov
Faculty of Pharmacy, Medical University – Pleven
Abstract. Chronic hepatitis C (CHC) is a socially signifi cant disease. Current therapeutic approaches for its treatment are based on combined interferon-free therapies including ombitasvir/ paritaprevir/ ritonavir/ dasabuvir/ ribavirin (OMВ/PAR/RIT/DAS/R), sofosbuvir/ledipasvir (SOF/LED), elbasvir/grazoprevir (ELB/GRA) and also the innovative pangenotypic therapies glecaprevir/pibrentasvir (GLE/PIB), sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX), grazoprevir/uprifosbuvir/elbasvir (GRA/UPR/ELB). The aim of presented study is to collect and analyze published data from assessments of health technologies for treatment of CHC in foreign countries, and to model expenses and health benefi ts of innovative pangenotypic therapies compared to other interferon-free therapies SOF/LED, ELB/GRA, OMB/ PAR/ RIT/ DAS/R; to make an indirect comparison of the therapeutic and cost-effectiveness of the alternatives for treatment of CHC based on network analysis. The results of ongoing assessment of health technologies for treatment of CHC are confi rmed by published data from similar relevant assessments made in foreign countries. Based on performed analyses, the conclusion can be drawn that in the group of interferon-free therapeutic alternatives for treatment of CHC in Bulgaria GLE/PIB and OMB/PAR/PIT/DAS/R dominate SOF/LED and ELB/GRA with a better therapeutic effi cacy and lower expenses per therapeutic course.
Key words: chronic hepatitis C, combined interferon-free therapies, innovative pangenetic therapies, assessments of health technologies, therapeutic and cost-effectiveness
Address for correspondence::   Prof. T. Vrkov, e-mail: t.vekov.mu.pleven@abv.bg

 

Awareness of Bulgarian women regarding the ways of prevention of sexually transmitted infections disorders - Detski i infectsiosni bolesti, V. 9, 2017, No 2, 35-38.
V. Irmov1 and P. Petrov2
1University Clinic „Deva Maria“ – Bourgas,
2MHAT “Eskulap” – Pazardzhik
Abstract. In the case of the Bulgarians, the number of women who have stated that they are fully aware of how to protect themselves against sexually transmitted infections is unsatisfactorily high. Only a 1/4 of all participants in the study are well aware of the methods and ways to protect against sexually transmitted infections. With the elevated education of the women surveyed also the relative share of women reporting that they know in details the ways and means of prevention of infectious diseases transmitted by sexual intercourse increased. We found that the age of the respondents infl uenced their knowledge of the methods for the prevention of infectious diseases transmitted by sexual intercourse. The presence of infectious diseases in the previous history of respondents also has an impact on their knowledge of the prevention of sexually transmitted infections.
Key words: prophylactics, literacy, infectious diseases, influence
Address for correspondence:   P. Retrov, MD, е-mail: dr.petroff@abv.bg

 

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1/2016

CHILD DISEASES

CASE REPORTS

Three cases of schizophrenia in adolescents with minimal physical anomalies and stuttering - Detski i infectsiosni bolesti, V. 9, 2017, No1, 9-12.
E. Ivanova1 and P. Manolova-Koleva2
1Clinic of Psychiatry, University Multiprofile Hospital for Active Treatment “Alexandrovska” – Sofia
2Center for Mental Health – Plovdiv
Summary. Three cases of adolescents with stuttering, with a subsequent debut of schizophrenia. The three patients were treated with risperidone (INN) at doses up to 4.5mg. All three have minimal physical anomalies (MРA), a gothic palate. Patients with schizophrenia and a large number of MРA more likely to have an unfavorable course of mental illness and manifestations of therapeutic resilience.
Key words: schizophrenia, gothic palate and stuttering
Address for correspondence: E. Ivanova, MD; GSM: 0895472527; е-mail: helen_aivan@abv.bg

 

INFECTIOUS DISEASES

ORIGINAL ARTICLES

Epidemiological characteristics of nosocomial outbreaks of the “indicator nosocomial infections” group in Bulgaria - Detski i infectsiosni bolesti, V. 9, 2017, No1, 29-32.
S. Angelova, Y. Mitova, V. Doycheva, Ts. Mincheva and N. Chumak-Tsaneva
Department „Epidemiology”, Medical University – Sofia
Summary. For the period 2005-2012, 16 outbreaks from the „nosocomial infection indicators“ group, with 81 affected persons, have been registered at the medical institutions for hospital care in Bulgaria. Thereof: sepsis – 47% (38 cases), pneumonia – 28% (23 cases) and surgical site infections (IHR) – 25% (20 cases). The high lethality of sepsis (18.4%) is indicative of the great weight and social importance of this clinical form. Leading etiological agents in the cases of nosocomial sepsis are K. pneumoniae and S. marcescens – 30%. The most common cause of hospital-acquired pneumonia and infection of the surgical wound is A. baumannii, 74% and 60%, respectively.
Key words: nosocomial infections, outbreaks, indicator infections, case, sepsis, pneumonia, surgical site
infection, medical establishments

Address for correspondence: S. Angelova, MD, e-mail: a.svetla.angelova@abv.bg



Investigation of the sensitivity of in vitro diagnostic veterinary medicine means with technique of fluorescent antibody test - Detski i infectsiosni bolesti, V. 9, 2017, No1, 33-36.

D. Ilieva.
National Diagnostic Research Veterinary Institute – Sofia
Summary. The sensitivity of the in vitro diagnostic veterinary medicine means (IDVM) for the rabies diagnosis by Fluorescent antibody test (FAT) is tested. It was found that the commercial kit, containing polyclonal antibodies, shows low sensitivity and cannot be used to obtain correct results in connection with the rabies diagnosis.
Key words: rabies/diagnosis, fluorescence antibody test, in vitro diagnostic veterinary medicine
Address for correspondence: Ass. Prof. D. Ilieva, National Diagnostic Research Veterinary Institute – Sofia; e-mail: emd@mail.orbitel.bg

 

CASE REPORT

Multiple sclerosis and lyme disease – a case report and literature review - Detski i infectsiosni bolesti, V. 9, 2017, No1, 37-40.
K. Drenska1, I. Dimitrov2, A. Kaprelyan1, T. Drenski3, D. Arabadzhieva1, V. Staneva4 and R. Georgiev5

1Department of Neurology and Neurosciences
2Department of Nursing, Sliven Branch of Medical University – Varna
3Intensive Care Unit, UMHAT ”Sv. Marina” – Varna
4UMHAT ”Sv. Marina” – Varna
5Department of Imaging Diagnostics and Radiotherapy, Medical University – Varna
Summary. During the recent years, a gradual increase of the number of cases with Lyme disease has been observed, including several regions in Bulgaria as well. Foreign papers analyzing the relationship of Lyme disease with a variety of neurological diseases, such as multiple sclerosis (MS), were published. In this article we report the case of a female patient with MS, in whom accompanying erythemic exudative gastritis as a manifestation of neuroborreliosis was diagnosed. The publications in the available literature devoted to the comorbidity and association between MS and Lyme disease are discussed.
Key words: multiple sclerosis, Lyme disease, neuroborreliosis, diagnosis
Address for correspondence: K. Drenska, MD, е-mail: k_drenska@abv.bg

Last update: 02.03.2018

 

 

 

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