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spisanie Detski i infektsiosni

Editor:
Central Medical Library ®,
MU - Sofia

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Journal "Detski i infectsiosni bolesti" (Pediatric and Infectious Diseases)

ORIGINAL PAPERS

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Vol. 4, 2012, № 2
INFECTIOUS DISEASES
ORIGINAL PAPERS

Ts. Doychinova, G. Gancheva, Hr. Tsvetanova, T. Petkova, Hr. Hristov and D. Shalamanov. CLINICAL AND EPIDEMIOLOGICAL STUDY OF RICKETTSIOSIS MARSELIENSIS IN THE PLEVEN REGION - Detski i infectsiosni bolesti, V. 4, 2012, No2, 8-12.

D. Ilieva. SURVEILLANCE OF RABIES DISEASE IN BULGARIA - Detski i infectsiosni bolesti, V. 4, 2012, No2, 13-18.

M. Karcheva, Ts. Valentinova and V. Nedkova. PREVALENCE OF ACUTE VIRAL HEPATITIS (B, C, D AND UNSPECIFIED) IN THE PLEVEN REGION - Detski i infectsiosni bolesti, V. 4, 2012, No2, 19-24.

K. Bojkova, T. Stoeva, V. Snegarova and M. Bojkova. ETIOLOGICAL SPECTRUM AND ANTIMICROBIAL SUSCEPTIBILITY OF THE CAUSATIVE AGENTS OF BACTERIAL MENINGITIS IN THE UNIVERSITY HOSPITAL “SV. MARINA” – VARNA FOR THE PERIOD 2002-2011- Detski i infectsiosni bolesti, V. 4, 2012, No2, 25-35.

CLINICAL CASE REPORTS

M. Daskalova, Tz. Doychinova, G. Gancheva, Hr. Tzvetanova and Hr. Hristov. CASE OF AN IMPORTED AMEBIASIS – CLINIC AND TREATMENT - Detski i infectsiosni bolesti, V. 4, 2012, No2, 36-40.

 

INFECTIOUS DISEASES

Ts. Doychinova, G. Gancheva, Hr. Tsvetanova, T. Petkova, Hr. Hristov and D. Shalamanov. CLINICAL
AND EPIDEMIOLOGICAL STUDY OF RICKETTSIOSIS MARSELIENSIS IN THE PLEVEN REGION
- Detski i infectsiosni bolesti, V. 4, 2012, No2, 8-12.
Summary: The trend in the prevalence of Marseilles fever in Bulgaria has shown upward move over the last two decades. Pleven region is not an endemic area and single cases occasionally occur. The aim of the study was to find the epidemiological, clinical and laboratory characteristics of the patients with Marseilles fever (MF) in the Pleven region. The study has used data from records of the National Center of Health Information and Regional Health Inspectorate – Pleven on MF morbidity in Bulgaria and the Pleven District. We performed a retrospective clinical-epidemiological analysis of data from the hospital records of 11 patients with MF, treated at the Clinic of Infectious Diseases at the University Multi-Profile Hospital for Active Treatment – Pleven in the period 2008-2011. MF cases in Pleven region are sporadic, with summer seasonal prevalence – 91% (10/11). The role of occupational risk factors (9% – 1/11) is reduced. All age groups catch the disease, especially urban residents (73% – 8/11). In 7 patients (64% – 7/11) there is evidence of contact with dogs and ticks. All patients have developed toxic infection syndrome and rash syndrome. In 9 patients (82%) the rash is papulose, in 2 (18%) – maculopapular, in 8 (73%) the rash is generalized, and in only 1 (9%) it is found on hands and feet. Craniopharyngeal syndrome was established in 91% (10/11), and tache noire – only in 6 patients (55%).The diagnosis was confirmed serologically in 9 patients (82%). Patients received integrated treatment. All patients were given Ciprinol. The outcome of the disease was positive in 100% of the patients. Marseilles fever is still sporadic disease in Pleven region. Its course is benign with no residual effects. It has good therapeutic response to quinolones.
Key words: Rikettsiosis marseliensis, endemicity, clinical course
Address for correspondence: Dr. Tsetsa Doychinova, Infectious Diseases Clinic, University Hospital- Pleven, Boulevard "D. Kochev" № 8a, 5800 Pleven, GSM: 0888729532, e-mail: doichinova_ceca@abv.bg

 

 

D. Ilieva. SURVEILLANCE OF RABIES DISEASE IN BULGARIA - Detski i infectsiosni bolesti, V. 4, 2012, No2, 13-18.
Summary: In 2011, in the NRL “Rabies and Monitoring the Effectiveness of the Vaccination", NDRVMI, Sofia, a total of 852 diagnostic samples were investigated in relation to rabies monitoring, as 36 of them were obtained from suspected animals and 816 were obtained from the wildlife. The effectiveness of oral vaccination against rabies was evaluated by the bait uptake tested for detecting the biomarker tetracycline in the teeth of the shot animals and serologically, by the ELISA. The results of the examinations of 444 blood serum samples of foxes and jackals for the anti-rabies antibody levels have revealed seroprevalence of 18.67% and 1.97%, in the foxes and jackals, respectively. The values of the oral tetracycline marker varied on average within 35% for the foxes and jackals. The data from the two tests have shown that the values of the seroprevalence and tetracycline are comparatively low, which mandatorily requires two oral campaigns annually. Genotyping of a field strain isolated from foxes in Bulgaria in 2011 has shown that it refers to the classical rabies virus (RABV, genotype 1). A genetic relationship with a perfect nucleotide identity (100%) between viral isolates from the Republic of Macedonia and 1 isolate from Bulgaria has been found, which clarifies the epizootic situation in the country and suggests that there
is a cross-border passage of animals infected with rabies.
Key words: rabies, oral vaccination, monitoring, genotyping, RABV, pet and wild life
Address for correspondence: Ass. Prof. dr Darinka Ilieva, DVM; NRL "Rabies control and efficiency
of vaccination ", National Diagnostic and Research Veterinary Institute, Boulevard "Pencho Slaveikov" № 15 A, 1606 Sofia;
e-mail: emd@mail.orbitel.bg

 


M. Karcheva, Ts. Valentinova and V. Nedkova. PREVALENCE OF ACUTE VIRAL HEPATITIS (B, C, D AND UNSPECIFIED) IN THE PLEVEN REGION - Detski i infectsiosni bolesti, V. 4, 2012, No2, 19-24.
Summary: In recent decades, the interest in hepatitis remains as it opened up new agents - viruses hepatitis C, D. The registration of cases of acute viral hepatitis without established etiological agent turns these infections into th subject of scientific research. The aim of this study is to present the frequency distribution of acute viral hepatitis B, C, D and unspecified in the Pleven region during the period 2000- 2011. Materials and Methods: Information from reports of Regional Healthcare Authority-Pleven, Bulgaria has been used; epidemiological analyses of the referenced information was performed. Results: The incidence of acute viral hepatitis type B was 10.2 per 100,000 population (the highest in 2001 - 15.65, the lowest in 2011 - 4.89) average for the period. The incidence of acute viral hepatitis type C is 1.48 (the highest in 2004 - 4.12, the lowest in 2006 - 0.66) average for the period. 63 cases of unspecified viral hepatitis were registered with morbidity 2.21 average for this period. For the study period, four cases of delta infection were recorded in 2007, with incidence 1.33. Conclusion: the introduction of immunization of hepatitis B in our country leads to reduced morbidity.
Key words: acute viral hepatitis, morbidity, epidemic process, prophylaxis
Address for correspondence: Prof. Milena Karcheva, Sector "Epidemiology" UM - Pleven Street "St. Kl. Ohridski "№ 1, 5800 Pleven, e-mail: milena_karcheva@abv.bg

 

K. Bojkova, T. Stoeva, V. Snegarova and M. Bojkova. ETIOLOGICAL SPECTRUM AND ANTIMICROBIAL SUSCEPTIBILITY OF THE CAUSATIVE AGENTS OF BACTERIAL MENINGITIS IN THE UNIVERSITY HOSPITAL
“SV. MARINA” – VARNA FOR THE PERIOD 2002-2011
- Detski i infectsiosni bolesti, V. 4, 2012, No2, 25-35.
Summary: Aims: to study the etiological spectrum and antimicrobial susceptibility of the causative agents of bacterial meningitis in patients from infectious and non-infectious wards in the University Hospital “St. Marina”, Varna for the period 2002 – 2011. A total of 917 clinical samples (cerebro-spinal fluids), collected from patients, hospitalized with the diagnosis of meningitis in the infectious and neurological wards and intensive care units were tested. Ninety clinically significant bacterial and fungal isolates were identified: S. pneumoniae, n = 19; NFB, n = 17; S. aureus, n = 14; Enterobacteriaceae spp., n = 12, N. meningitidis, n = 8; Enterococcus spp., n = 6, L. monocytogenes, n = 6; H. influenzae, n = 3; S. agalactiae, n = 2, C. neoformans, n = 3. A trend of increasing the number of clinical cases caused by penicillinnonsusceptible S. pneumoniae, MRSA, as well as Enterobacteriaceae spp., producers of extended spectrum beta-lactamases (ESBL) and carbapenem – resistant NFB was detected. Cases of meningitis caused by Cryprococcus neoformans were identified too.
Key words: bacterial meningitis, etiological spectrum, antimicrobial susceptibility
Address for correspondence: Dr. Kalinka Bozhkova, MD; Department of Microbiology and Virology
Medical University; Street " Marin Drinov" № 55; 9002 Varna; e-mail: kbojkova7@abv.bg


CLINICAL CASE REPORTS

M. Daskalova, Tz. Doychinova, G. Gancheva, Hr. Tzvetanova and Hr. Hristov. CASE OF AN IMPORTED AMEBIASIS – CLINIC AND TREATMENT - Detski i infectsiosni bolesti, V. 4, 2012, No2, 36-40.
Summary: Entamoeba histolytica, an antroponotic protozoan intestinal parasite, is the causative agent of human amoebiasis, which is clinically presented as amoebic dysentery (amoebic colitis) and/or extraintestinal amebiasis, affecting the liver, lungs, brain, etc. Amebiasis is the fourth leading cause for mortality and third leading cause for morbidity due to protozoan infections worldwide. We present the clinical study of a case with a severe amoebic colitis treated at the Clinic of Infectious Diseases of the University Hospital Dr. Georgi Stranski Pleven in 2011.The disease began with subacute abdominal pain and loose 5-6-7 malodorous stools intermingled with mucus, and clear blood. There was no vomiting and fever. The patient did not keep diet. She was treated with drugs from the general practitioner and later was hospitalised at MHAT, Sevlievo, with no improvement. The defecations increased, became liquid mucusbloody and the child was transfered without epicrisis in the University Hospital – Pleven. Therapy was conducted with intravenous Metronidazole for 10 days and Resohin for 5 days with instructions to continue the treatment for 14 days. Parents stools were evaluated twice and showed negative results. Amebiasis is a serious disease that requires early diagnosis and adequate etiological treatment.
Key words: amebiasis, E. histolytica, epidemiology, etiological treatment
Address for correspondence: Dr. Milena Daskalova, tel.064 / 884174, 064/886357, e-mail: dr.mdaskalova @ abv.bg

 

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Vol. 4, 2012, № 1

PEDIATRIC DISEASES
Original papers

Dz. Grozdanova. SCHOOL CHILDREN’S DENTAL HEALTH – THE RESULT OF THE DIRECT INTERACTION BETWEEN PARENTS, TEACHERS AND DENTISTS. - Detski i infectsiosni bolesti, V. 4, 2012, No1, 3-8.

S. Mihaylova, M. Stoynovska, V. Birdanova and D. Shalamanov. PARENTS’ KNOWLEDGE OF VACCINE-PREVENTABLE DISEASES, FOR WHICH PROPHYLAXIS IS PERFORMED AS PER THE IMMUNIZATION SCHEDULE OF THE REPUBLIC OF BULGARIA - Detski i infectsiosni bolesti, V. 4, 2012, No1, 9-16.

S. Pavlova, T. Hadzhiolova and R. Kotseva. INFLUENZA AND ACUTE RESPIRATORY DISEASES DIAGNOSTIC INVESTIGATIONS DURING THE 2008/2009 SEASON . - Detski i infectsiosni bolesti, V. 4, 2012, No1, 17-23.

INFECTIOUS DISEASES
Original papers

Y. Stoilova, N. Petrova and R. Raycheva. EFFECTIVE VACCINES – A LONG-ACTING CAUSE OF THE MODELING OF INFECTIOUS DISEASES MORBIDITY - Detski i infectsiosni bolesti, V. 4, 2012, No 1, 24-33.


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Dz. Grozdanova. SCHOOL CHILDREN’S DENTAL HEALTH – THE RESULT OF THE DIRECT INTERACTION BETWEEN PARENTS, TEACHERS AND DENTISTS - Detski i infectsiosni bolesti, V. 4, 2012, No1, 3-8.
Summary. The recent changes in the health care system in Bulgaria ensured patients’ access and free choice. However, certain challenges remained to the families, dental profession and government health policy of ensuring an adequate dental care and prevention for the school children. The aim of the study is to show the level of knowledge and engagement of parents, teachers and dentists in the process of educating school children in dental health. Methods: a direct anonymous survey and dental examination. Materials: 250 children and their parents, 30 teachers and 50 dentists were enrolled in the study. Results: 70% of children do not receive any information on dental health from the school. 52% of children visited a dentist for the first time due to pains. 82% of parents state that school dental offices should be restored. 90% of teachers would willingly participate in programs for cooperative dental prophylaxis, including children, parents and dentists. 55% of dentists  approve of the school dental offices. The Ep index increases with age; the caries intensity (Id) in adolescent girls is higher compared to the boys of the same age. Conclusions: In their work with school children, dentists should orient their efforts towards prevention and education for better oral health.
Key words: school children, dental health, education, oral health programs
Address for correspondence: Dr. Dzemma M. Grozdanova, Ph.D.- researcher; Department of child dentistry, Faculty of dentistry, MU Sofia; GSM: 0889 239477; e-mail j_grozdanova@abv.bg

 

S. Mihaylova, M. Stoynovska, V. Birdanova and D. Shalamanov. PARENTS’ KNOWLEDGE OF VACCINE-PREVENTABLE DISEASES, FOR WHICH PROPHYLAXIS IS PERFORMED AS PER THE IMMUNIZATION SCHEDULE OF THE REPUBLIC OF BULGARIA - Detski i infectsiosni bolesti, V. 4, 2012, No1, 9-16.
Summary. Immunization with modern vaccines is the safest and the most efficacious way of preventing a number of infections. The aim of the present study is to assess parents’ knowledge of the infectious diseases, for which vaccine prophylaxis is performed as per the Immunization schedule of the country. A direct individual inquiry took place among 400 parents. Their knowledge was evaluated with a 5-point scale. The highest levels of knowledge were ascertained in relation to the clinical manifestations and epidemiology of tuberculosis, and the lowest levels of knowledge were demonstrated in relation to the clinical presentations of diphtheria and the epidemiology of poliomyelitis. One third of parents are with very good and excellent overall knowledge about the infections, for which vaccine prophylaxis is performed as per the Immunization schedule. Further efforts need to be directed towards the increase of the knowledge of all vaccine-preventable diseases by organizing programs for health education of parents.
Key words: parents’ knowledge, vaccine-preventable diseases, immunization schedule
Address for correspondence: Dr. Sasha Mikhailova; Sector "Medical and diagnostic research"; Medical University - Pleven; Street "St. Kliment Ohridski "№ 1; 5800 Pleven; GSM: 0899116516; e-mail: sashkam@yahoo.com

 

S. Pavlova, T. Hadzhiolova and R. Kotseva. INFLUENZA AND ACUTE RESPIRATORY DISEASES DIAGNOSTIC INVESTIGATIONS DURING THE 2008/2009 SEASON - Detski i infectsiosni bolesti, V. 4, 2012, No1, 17-23.
Summary. The summary of the diagnostic investigations performed in the Laboratory of Influenza and ARD, NCIPD, during the 2008/2009 season is presented. All of the samples (n = 860) were tested for influenza virus isolation on cell culture/chicken embryos. Molecular-biology tests: Real-time reverse transcription PCR (rRT-PCR) for influenza and RT-PCR for respiratory syncytial virus (RSV) and human metapneumonia virus (hMPV) were used for testing of 371 samples obtained from children up to five years of age. In addition, 311 sentinel samples from Regional Inspectorates were tested by rRT-PCR. Given the small number (33 of 860 samples) of the cases of the positive detection of influenza viruses, we found that the number of positive for RSV and hMPV samples was relatively high. The coinfection due to RSV, AdV and hMPV in two outbreaks in orphanages was deciphered.
Key words: the 2008/2009 season, flu viruses, acute respiratory diseases viruses, diagnosis
Address for correspondence: Dr. R. Kotseva, MD; National Center of Infectious and Parasitic Diseases; Boulevard "Stoletov" 44 A; 1233 Sofia; e-mail: kotseva@ncipd.org

 

INFECTIOUS DISEASES
ORIGINAL PAPERS

Y. Stoilova, N. Petrova and R. Raycheva. EFFECTIVE VACCINES – A LONG-ACTING CAUSE OF THE MODELING OF INFECTIOUS DISEASES MORBIDITY - Detski i infectsiosni bolesti, V. 4, 2012, No 1, 24-33.
Summary. The trend of morbidity is the most important element in the development of epidemic process and designs the basic direction in the multiannual dynamics of infectious morbidity as a function of timeperiod. The model of morbidity is a result of rectifying the curve under the influence of the causes of different types (durably, temporarily and cyclically acting). Mass vaccinations are strong and typical long-acting causes, proven for decades. The aim of the study is to examine the result of the administration of effective vaccinations as a lon-acting cause of the modeling of the morbidity of infectious diseases. Material and methods: 9 infectious diseases were studied that have a long term registration and mass vaccination in Bulgaria. Modeling the trend was by the ‘least-squares method’ ∑(Y - Yt )² /(n – 1). Correlation analysis was performed by the determination of correlation coefficient (r) and its range value. Mass immunizations with effective vaccines, defined as long-acting systematic causes of category of necessity function regularly during the whole study period and shape two groups of diseases: for eradication – variola smallpox, morbilli, pertussis, poliomyelitis, viral hepatitis B, and for elimination – diphtheria and tetanus. The trend line is a model of the dynamic regularity of these diseases and the result of employed vaccines. The range of equation of the rectifying line renders epidemiological information about the morbidity model: the average annual morbidity and its average annual decrease, the correlation coefficient and its range value of the power and direction of the relation morbidity – determining it causes-time period. The models of morbidity trend interpreted by determining causes of influence in time-period gives us the possibility to evaluate and improve the system for surveillance and control of this pathology.
Key words: effective vaccines, morbidity trend, long- and cyclically acting causes
Address for correspondence: Yordanka Stoilova; Sector "Epidemiology"; Department of "Hygiene, Ecology and Epidemiology"; Medical University - Plovdiv; "Vasil Aprilov" Street № 15a; 4002 Plovdiv;
GSM: 032 602 892

 

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Last update: 10.07.2013