Original articles: Vol. 11, 2017


Famous physicians

Scientific reviews

Original articles

Clinical practice


Vol 11, 1/2017

Vol 11, 2/2017

Vol 11, 3/2017


arrow Vol. 11, 3/2017


Clinical laboratory


Investigating the effect of aronia melanocarpa fresh fruit juice intake on changes in laboratory parameters for oxidative stress in patients with type 2 diabetes mellitus ) - Bulgarian medical journal (Български медицински журнал), 11, 2017, № 3, 42-48.
M. Boncheva1, V. Madjova1 and H. Madjova2
1Department of General Medicine and Clinical Laboratory,
2Department of Conservative Dentistry and Oral Pathology, Medical University – Varna
The authors investigate the effects of Aronia melanocarpa juice intake on oxidative stress and anti-oxidant plasma barrier in 48 Type 2 diabetes mellitus patients of various age groups. All subjects have taken 70 ml of juice three times daily over a period of 60 days. Changes in Carratelli panel have been followed which includes – SHp test, OXY-adsorbent test, LP CHOLOX test, anti-ROMs test, d-ROMs test and BAP test – to assess the oxidative stress metabolites and the total anti-oxidant plasma capacity. The results obtained suggest the following: a considerable decrease in reactive oxygen substances; a considerable decrease in lipid peroxidation; moderate elevation of plasma barrier with aspect to the thiol radicals action; a significant positive effect on quickly-acting anti-oxidants and a moderate effect on slow-acting antioxidants; a somewhat weaker effect on the anti-oxidant barrier against hypochlorous acid radicals; a pronounced increase in biological anti-oxidant potency of plasma barrier. A daily supplement of aronia juice to one’s routine diet regulates the quantity of oxidative active radicals – free radicals (ROS). Alongside, the anti-oxidant capacity of blood plasma is improved. We recommend the daily intake of Aronia melanocarpa fruit juice as a vital functional food for patients with TYPE 2 diabetes mellitus.
Key words: aronia melanocarpa, type 2 diabetes mellitus, oxidative stress, Carratelli panel
Address for correspondence:
Prof. Margaritka Boncheva, MD, Department of General Medicine and Clinical Laboratory, Medical University, 55 Prof. Marin Drinov Str., Bg – 9002 Varna, e-mail: mbon@mail.bg



arrow Vol. 11, 2/2017


Clinical laboratory

Effect of professional chronic radiation exposure on some biological parameters of working in NPP Kozloduy. A statistical analysis and classification of the studied laboratory parameters by the degree of their diagnostic significance - Bulgarian medical journal (Български медицински журнал), 11, 2017, №2,  22-30.
V. Rangelov, Pl. Petrunov, M. Hristozova, V. Vaseva and R. Popov

Military Medical Academy – Sofia
Abstract. The radiation impact in professional conditions for persons working in nuclear power plants is characterized by having low doses and low dose rates. It is characterized as a chronic, protracted, low-dose irradiation. It was conducted generalized correlation and variation analysis of the studied professional contingent to establish the relationship between age, dose and length of service. The curves of the expected distribution of the data were calculated by the method of distance weighted least squares (DWLS) which is one of the most accurate statistical methods. It was conducted a statistical survey on the extent of the difference of each examined indicator compared to the control group data. Based on statistical analysis we received „Classifi cation of signifi cance“ of the most diagnostically important parameters. These are 29 indicators listed by the weighting factor of importance o f the diagnostic severity, degree of their importance and their propensity to respond to this professionally damaging factor.
Key words: ionizing radiation, low doses, chronic occupational exposure, NPP, hematological parameters, health monitoring
Address for correspondence: Assoc. Prof. Plamen Petrunov, MD, PhD, Department of Radiobiology, Military Medical Academy, 3 G. Sofi isky St., Bg – 1606 Sofi a, e-mail: p_petrunov@yahoo.co.uk


The tuberculosis foci and distribution in children population in Bulgaria - Bulgarian medical journal (Български медицински журнал), 11, 2017, №2, 31-35.

E. Georgieva
University Pediatric Clinic of Pulmonary Diseases, MHATPD “Sveta Sofia”
Abstract. 1 900 900 000 people are infected with tuberculosis. 8,800,000 people develop an active disease every year. Today tuberculosis is a problem for our healthcare again. Purpose of the study: To present the centers of tuberculosis among the children population in Bulgaria. Material and Methods: A retrospective study (2010-2014) of 945 children who received diagnosis and treatment at the University Children’s Clinic of Pulmonary Diseases at the Hospital „Sveta Sofia“ in Sofi a. 90% of the children with latent and active tuberculosis are hospitalized in the clinic. Results and discussion: The disease is most common after contact with the mother – in 22% of cases, as well as in families with more than one patient – 23.2%. The most children with active form of tuberculosis are in Sofi a and the Sofi a district – centers with the highest density of population, and in Vratsa – a part of northwestern Bulgaria, in a population with very low social status.
Key words: tuberculosis, childhood, outbreaks
Address for correspondence: Еlena Georgieva, MD, University Pediatric Clinic of Pulmonary Diseases, MHATPD “Sveta Sofia”, 19 Akad. Iv. E. Geshov bvl., Bg  1606 Sofi a, e-mail: goell@abv.bg

Infectology and epidemiology

Epidemiological characteristics of nosocomial outbreaks of classic infections with a parenteral route of transmission in Bulgaria - Bulgarian medical journal (Български медицински журнал), 11, 2017, №2, 36-39.
S. Angelova, Y. Mitova-Mineva, V. Doycheva, Ts. Mincheva and E. Petrova
Department “Epidemiology”, Medical University – Sofia
Abstract. The purpose of the present study is to make an epidemiological characterization of hospital outbreaks of classical infections with a parenteral route of transmission in Bulgaria. For the period 2005-2012 at hospital are offi cially registered 4 outbreaks of classical infections with a parenteral route of transmission or the former are approximately 4% of all reported 93 outbreaks of nosocomial infections in Bulgaria for the period. All offi cially registered outbreaks of classical infections with a parenteral route of transmission are caused of HCV, but in one of them it is concurrently isolated HBV, too. Outbreaks of HCV occurred after an infusion therapy.
Key words: nosocomial infections, outbreaks, classical infections/parenteral route of transmission, HCV, hospitals
Address for correspondence: Dr S. Angelova, Department “Epidemiology”, Medical University, University Obstetrics and Ginecology Hospital ”Maychin dom” fl . 6, 665, 2 Zdrave str., Bg – 1431 Sofi a, e-mail: a.svetla.angelova@abv.bg

Infection of the surgical site in wards with a surgical profi le in Bulgaria, 2016 - Bulgarian medical journal (Български медицински журнал), 11, 2017, №2,  40-44.
Y. Mitova1, V. Doycheva1, S. Angelova1 and V. Vodenicharov2

1Department of Epidemiology; 2Department of Hygiene, Medical Ecology and Nutrition, Medical University – Sofia
Abstract. Surgery site infection is the main clinical form in surgical wards. The relative share of surgery site infection in all nosocomial infections in the general and abdominal surgery wards in Bulgaria for the period 2016 was 61.92%. The incidence of surgery site infection among surgical patients in different surgical wards in Bulgaria for 2016 varies between 0.14% for urological wards and 0.76% for general and abdominal surgery wards. The relative share of superfi cial surgery site infection is highest in urological wards (95.51%), deep surgery site infection – in orthopedic wards (27.82%) and the infection in the surgical site affecting the organ and/or the cavity in chest surgical wards (29.79%). E. coli is the leading etiological agent in both superfi cial surgery site infection and organ and cavity infections in general and abdominal surgery. Staphylococcus aureus is the leading etiological agent of superfi cial surgery site infection in breast surgery, cardiovascular surgical wards and orthopedic wards in Bulgaria.
Key words: Surgery site infection, nosocomial infections, distribution, clinical structure, causative agents.
Address for correspondence: Yordanka Mitova-Mineva, MD, Department of Epidemiology, Medical University, 2 Zdrave St., Bg – 1431 Sofia, e-mail: drmitova@mail.bg




Fever of unknown origin - first diagnostic algorithm for Bulgaria - Bulgarian medical journal (Български медицински журнал), 11, 2017, №2,  51-55.
M. Baymakova, G. Popov, R. Andonova, V. Kovaleva, I. Dikov and K. Plochev

Department of Infectious Diseases, Military Medical Academy – Sofia
Abstract. Fever of unknown origin (FUO) is an interesting medical problem. The solving of this condition requires a profound and diverse medical knowledge in the fi elds of infectious diseases, rheumatology, oncology, nuclear medicine and others. The causes of FUO are more than 200 diseases wherefore the existence of diagnostic algorithm is signifi cant and practical. The aim of the study is to present the fi rst Bulgarian diagnostic protocol in case of fever of unknown origin.
Key words: fever of unknown origin, diagnostics, infectious diseases, non-infectious infl ammatory diseases, neoplasms
Address for correspondence: Magdalena Baymakova, MD, PhD, Department of Infectious Diseases, Military Medical Academy, 3 Sv. Georgi Sofi yski St., Bg – 1606 Sofi a, e-mail: dr.baymakova@gmail.com




arrow Vol. 11, 1/2017


Laser therapy

Non medication treatment of rosacea - Bulgarian medical journal (Български медицински журнал), 11, 2017, №1, 36-40.
K. Krahtova1, K. Nastev2 and A. Zlatareva3

1Department of Infectious Diseases, Parasitology and Dermatovenereology, Faculty of Medicine, Medical
University – Varna
2Multiprofi le Hospital for Active Treatment „Skin systems”
3Department of Economics and Health Care Management, Faculty of Public Health, Medical University – Varna
Abstract. The basic principles of low-frequency laser therapy, are multifactorial simultaneous effect of pulsed infrared laser radiation, pulse broadband infrared radiation, pulsating red light and static magnetic fi eld of patient. By main healing factor of impulse monochromatic infrared light  narrow band, alternately in space and in time, and highly polarized  are stimulated circulation and cell membrane metabolism of the human body, are activated neurohumoral factors and immunocompetent systems to harmonize metabolism. The purpose of this study is to prove the therapeutic effect of the application of low-intensity laser therapy in a response to the main symptoms in patients with rosacea.
Key words: rosacea, low-intensity laser therapy
Address for correspondence: Katrin Krahtova, FM, MU – Varna, e-mail: dockrahtova@yahoo.com


Narcotic substance abuse by vehicle drivers from North-East Bulgaria during 2016. - Bulgarian medical journal (Български медицински журнал), 11, 2017, №1, 41-44.
G. Bonchev1, Sn. Zlateva1, P. Marinov1, M. Yovcheva1 and Iv. Vazharov2

1Clinic of Intensive Treatment of Acute Intoxications and Toxicoallergies,
Military Medical Academy – Naval Hospital – Varna
2Clinic of Internal Diseases, Military Medical Academy – Naval Hospital – Varna
Abstract. During the period of July 2016–December 2016, 19 requests by the Traffi c Police for confi rmatory toxicological chemical analysis of biological samples from vehicle drivers from North-East Bulgaria have been received in the Laboratory of Chemical Toxicological Investigations. Presence of narcotic substances and/or their metabolites was proved in more than 80% of the samples, by gas-chromatographic methods. A very large portion of the results corresponded fully with the preliminary data from the technical equipment used by Ministry of Internal Affairs authorities. The chemical expert’s report indicated the prevalence of amphetamine abuse (a total of 67% of the positive samples), followed by marihuana (15%) and opiates (12%). The authors draw attention to the drastically big share of polyvalent intoxications – 3 of every 4 cases of abuse were found to be a combined intake of two or more narcotic substances.
Key words: narcotic substances, Traffi c Police Control, Law of Road Traffi c, Decree 30, vehicle drivers
Address for correspondence: Georgi Bonchev, Military Medical Academy, Naval Hospital, 3 Hristo Smirnenski St., Bg  9000 Varna, e-mail: toxilab.varna@abv.bg

Public health protection

Bisphenol A problem in Bulgaria – first studies - Bulgarian medical journal (Български медицински журнал), 11, 2017, №1, 45-51.
Sv. Chavdarova, T. Barakova and T. Vrabcheva

National Center for Public Health and Analyses
Abstract. Bisphenol A (BPA) is a chemical substance used mainly in the production of polycarbonate plastics, epoxy resins and as non-polymeric additive to other plastics. Polycarbonates produced from bisphenol A typically have good optical clarity, and impact resistant and are elastic at room temperature and at a lower temperature. This makes them ideal in the making of various products for use: baby feeding bottles, containers for microwave ovens, containers for storing food, bottles and containers for mineral and plain water. Bisphenol A is also used to coat the inside of metal cans for food and beverages. The cover is needed to protect against corrosion of cans and contamination of food and beverages with dissolved metals. It also helps to protect canned foods from bacterial contamination, keeping quality and taste of food. The interest on the bisphenol A was due to the fact that it is a compound that binds to an estrogen receptor and therefore it is considered as an „endocrine disruptor“. It is known for its toxicity to the reproductive and nervous system. The main objective of this work was to make the fi rst Bulgarian studies on specifi c migration of bisphenol A. There were investigated polycarbonate containers for water, soft drinks stored in metal cans with epoxy coating, and baby feeding bottles and cups.The used method was HPLC with FL detection.
Key words: Bisphenol A, migration, polycarbonate plastics, epoxy coatings
Address for correspondence: Sv. Chavdarova, National Center for Public Health and Analyses, 15 „Akad. Ivan Geshov“, Blvd. Bg – 1431 София, tel.: 02/8056391, e-mail: t.vrabcheva@ncpha.government.bg



Epidemiology and control of vector-transmissible zoonosis tularaemia - Bulgarian medical journal (Български медицински журнал), 11, 2017, №1, 52-60.
D. Ilieva1 and E. Iliev2

1National Diagnostic Research Veterinary Medical Institute – Sofia
2Bulgarian Food Safety Autority
Abstract. In the scientifi c publication is considered contemporary data for vector transmissible zoonotic disease tularemia. Through the schematic presentation of the epidemic chain of tularemia vectors and reservoirs for incidence the infection are identifi ed. The large number of diverse carriers creates opportunities for contamination of different kinds of animals (wild and domestic). The appearance and spread of tularaemia can lead to serious direct and indirect economic losses to livestock, and the seropositive animals-carriers of the agent, create a risk for the human health.
Key words: tularemia, epidemic chain, serological tests, foxes, jackals
Address for correspondence: Assoc. Prof. Darinka Ilieva, National Diagnostic Research Veterinary Medical Institute, 15A Pencho Slaveykov Blvd., Bg – 1606 Sofi a, e-mail: emd@mail.orbitel.bg




Last update: 06.02.2018

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